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It is now well established that transient granulocytopenia is common in patients during the initial phase of hemodialysis with new cuprophane membrane, but not with reused nembrane, or some synthetic membranes. In this study, new cuprophane dialyzer was treated with plasma and albumin, respectively, then, peripheral blood leukocytes were counted at the onset and after 15 minute of hemodialysis. In the plasma-treated group, the percent of leukopenia was less (41.3 %) than control group (71.3 %). In the plasmatreated group, the degree of leukopenia was close to that ot’’’’control grou p. The protective factor, therefore is thought to be present in the plasma other than albumin fraction.
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